Gd-Diclofenac/Misoprostol 75

ODB Formulary Therapeutic Classification

• 28:08:04 Nonsteroidal Anti-Inflammatory Agents

Therapeutic Note

Diclofenac Sodium + Misoprostol 75 mg + 200 mcg Tablet: NSAIDs have a high rate of serious adverse effects in the elderly. When prescribing NSAIDs, the minimal effective dose for the shortest period of time should be used. In nonspecific pain and/or osteoarthritis, in the absence of joint inflammation (swelling), acetaminophen is a better first choice for analgesia. The most effective treatment to prevent NSAID-gastritis is misoprostol; although H-2 antagonists, such as ranitidine or cimetidine, are commonly used, they are not as effective. NSAIDs can significantly aggravate hypertension and congestive heart failure; ASA in doses below 1 gram per day is a better choice than other NSAID options if anti-inflammatory effects are required in patients with these conditions. Low dose ASA has additional benefits for anti-platelet indications that are not provided by other NSAIDs, and should be given in preference or in addition to other NSAIDs for patients with vascular indications.

ATC Code

M01AB55

Interchangeable Products

 

LU Clinical Criteria

NO  

EAP Criteria

NO

Product Monograph

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