Product Details

Bimzelx

Bimekizumab
160 mg/mL
Solution for Injection
1-mL Prefilled Autoinjector (Preservative-Free)

DIN/PIN/NPN

02525275

Manufacturer

UCB Canada Inc.

Formulary Listing Date

2023-03-31  

Unit Price

1625.0000

Amount MOH Pays

1625.0000

Coverage Status

Limited Use Product

ODB Formulary Therapeutic Classification

Therapeutic Note

NO

ATC Code

L04AC21

Interchangeable Products

NO  

LU Clinical Criteria

LU Code Auth. Period Clinical Criteria
641 1 year

For the treatment of severe (see Note 1 below) plaque psoriasis in patients 18 years of age or older who have experienced failure, intolerance, or have a contraindication to adequate trials of several standard therapies (see Note 2 below).

Claims for the first 6 months must be written by a dermatologist. Monitoring of patients is required to determine if continuation of therapy beyond 12 weeks is required. Patients not responding adequately at 12 weeks should have treatment discontinued.

Note 1: Definition of severe plaque psoriasis:

- Body Surface Area (BSA) involvement of at least 10%, or involvement of the face, hands, feet or genital regions, AND

- Psoriasis Area and Severity Index (PASI) score of at least 10 (not required if there is involvement of the face, hands, feet or genital regions), AND

- Dermatology Life Quality Index (DLQI) score of at least 10.

Note 2: Definition of failure, intolerance or contraindication to adequate trials of standard therapies:

- 6-month trial of at least 3 topical agents including vitamin D analogues and steroids, AND

- 12-week trial of phototherapy (unless not accessible), AND

- 6-month trial of at least 2 systemic, oral agents used alone or in combination

- Methotrexate 15-30mg per week

- Acitretin (could have been used with phototherapy)

- Cyclosporine

 

Maintenance/Renewal:

After 3 months of therapy, patients who respond to therapy should have:

- at least a 50% reduction in PASI, AND

- at least a 50% reduction in BSA involvement, AND

- at least a 5-point reduction in DLQI score

 

Approvals will only allow for standard dosing for Bimzelx 320mg subcutaneously every 4 weeks for the first 16 weeks, and every 8 weeks thereafter. If the patient has not responded adequately after 16 weeks of treatment at the Health Canada approved dose, higher doses are not recommended and the physician should consider switching to an alternative biologic agent.

 

EAP Criteria

NO

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